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Allergierisiko: Erstgeborene stärker gefährdet

Laut einer neuen japanischen Studie unter der Leitung von Dr. Takashi Kusunoki haben Erstgeborene ein höheres Risiko an einer Lebensmittelallergie sowie Heuschnupfen zu erkranken als die nachfolgenden Geschwister.Die Ergebnisse der Studie wurden auf dem Kongress der „American Academy of Allergy, Asthma & Immunology“ vorgestellt. Die Organisation trifft sich vom 18. bis zum 22. März in San Francisco.

Die Forscher hatten mehr als 13.000 Kinder zwischen 7 und fünfzehn Jahren beobachtet und befragt. Bei der Auswertung wurde vor allem die Geburtsreihenfolge unter die Lupe genommen und mit dem Auftreten von Allergien verglichen.

Kusunoki erklärt: „Es ist festgestellt worden, dass Individuen mit absteigender Geburtsfolge ein jeweils kleineres Risiko für Allergien haben. Allerdings schwankt die Bedeutung dieses Effekts bei verschiedenen allergischen Erkrankungen“.

So konnten die Wissenschaftler nur bei Heuschnupfen und Allergien, die Bindehautentzündungen zur Folge haben, einen Zusammenhang feststellen. Je weiter unten ein Kind in der Geburtsreihenfolge der Geschwister steht, desto geringer ist das Allergierisiko. Bei Lebensmittelallergien hat das Erstgeborene ein 4-prozentiges Risiko, das Zweitgeborene ein 3,5-prozentiges Risiko, alle danach kommenden Kinder haben nur ein 2,6-prozentiges Risiko, an einer Lebensmittelallergie oder Heuschnupfen zu erkranken. Bei Asthma oder Ekzemen aufgrund von Kontaktallergien konnte hingegen kein Zusammenhang gefunden werden.

Bereits 2008 hatte eine britische Studie gezeigt, dass sich die Bedingungen im Mutterleib bei dem Erstgeborenen sowie dessen Geschwistern unterscheiden. Die Forscher um Wilfried Karmaus von der Universität von South Carolina in Columbia untersuchten das Nabelschnurblut von 1200 Neugeborenen und maßen den für Allergien relevanten Antikörper IgE im Nabelschnurblut. Bei den Erstgeborenen konnte der Antikörper häufiger nachgewiesen werden.

Quelle: gegenkopfschmerzen.de, Pressemitteilung der American Academy of Allergy, Asthma & Immunology

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